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Photosensitizing proteins for antibacterial photodynamic inactivation
(Wiley-VCH Verlag, 2020-05)
We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their ...
Assessing amphiphilic ABAB Zn(II) Phthalocyanines with enhanced photosensitization abilities in In Vitro photodynamic therapy studies against cancer
(MDPI, 2020-01)
We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., ...
Octanol-water partition coefficients of highly hydrophobic photodynamic therapy drugs: a computational study
(Asociación de Químicos e Ingenieros del Instituto Químico de Sarrià, 2013-10)
Photodynamic therapy is a novel treatment for solid tumors based on the selective induction of cell death by the generation of cytotoxic reactive oxygen species within neoplastic tissues. Oxygen ...
Assessing the potential of photosensitizing flavoproteins as tags for correlative microscopy
(Royal Society of Chemistry, 2016-06)
Photosensitizing flavoproteins have great potential as tags for correlative light and electron microscopy (CLEM). We examine the
photostability of miniSOG mutants and their ability to photooxidize ...
Riboflavin-binding proteins for singlet oxygen production
(Springer, 2022)
miniSOG, developed as the first fully genetically encoded singlet oxygen photosensitiser, has found various applications in cell imaging and functional studies. Yet, miniSOG has suboptimal properties, ...
Porficenos para la fotoquimioterapia del cáncer y otras aplicaciones biomédicas
(Asociación de Químicos e Ingenieros del Instituto Químico de Sarrià, 2002)
La terapia fotodinámica (PDT) o fotoquimioterapia del cáncer es una modalidad terapéutica que consiste en la aplicación de compuestos fotosensibilizadores que se acumulan preferentemente en tejidos ...
A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents
(Royal Society of Chemistry, 2014-12)
Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The ...
Subdiffraction localization of a nanostructured photosensitizer in bacterial cells
(Nature Research, 2015-10)
Antibacterial treatments based on photosensitized production of reactive oxygen species is a promising approach to address local microbial infections. Given the small size of bacterial cells, identification ...
A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation
(MDPI, 2015-11)
Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial ...
Morphology effects on singlet oxygen production and bacterial photoinactivation efficiency by different silica-protoporphyrin IX nanocomposites
(The Royal Society of Chemistry, 2017-03)
Different silica-protoporphyrin IX (PpIX) nanocomposites have been synthesized to evaluate the dependence of singlet oxygen production and bacterial inactivation efficiency on the morphology of the ...