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Optimization of 3D autologous chondrocyte-seeded polyglycolic acid scaffolds to mimic human ear cartilage
(Royal Society of Chemistry, 2023-05)
Auricular reconstruction in children with microtia is one of the more complex procedures in plastic surgery. Obtaining sufficient native material to build an ear requires harvesting large fragments of ...
Zwitterionic 3D-printed non-immunogenic stealth microrobots
(Wiley, 2020-08)
Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a ...
Extracellular vesicles and their current role in cancer immunotherapy
(MDPI, 2021-05-10)
Extracellular vesicles (EVs) are natural particles formed by the lipid bilayer and released from almost all cell types to the extracellular environment both under physiological conditions and in presence ...
Nanomedicine in non-small cell lung cancer: from conventional treatments to immunotherapy
(MDPI, 2020-06)
Non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related mortality. The heterogeneous nature of this disease hinders its diagnosis and treatment, requiring continuous advances ...
Photosensitive EGFR-Targeted Nanocarriers for Combined Photodynamic and Local Chemotherapy
(MDPI, 2022-02)
The major limitation of any cancer therapy lies in the difficulty of precisely controlling the localization of the drug in the tumor cells. To improve this drawback, our study explores the use of ...
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles for the co-delivery of DOX/CPT-PEG for targeting HepG2 cells
(MDPI, 2020-11)
A pH-triggered mesoporous silica nanoparticle (MSN)-based nano-vehicle for the dual delivery of doxorubicin (DOX)/camptothecin-PEG (CPT-PEG) has been prepared. To enhance its selectivity, the nanoparticles ...
Site-specific antibody masking enables conditional activation with different stimuli
(Elsevier, 2023-12)
Antibody therapeutics show great potential to treat a variety of diseases. Often, the dose that can be safely administered is limited by side effects that arise from the interaction with the target ...
Oligopeptide-modified poly(beta-amino ester)s-coated AdNuPARmE1A: boosting the efficacy of intravenously administered therapeutic adenoviruses
(Ivyspring International Publisher, 2020-02)
Oncolytic adenoviruses are used as agents for the treatment of cancer. However, their potential is limited due to the high seroprevalence of anti-adenovirus neutralizing antibodies (nAbs) within the ...
Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma
(BioMed Central, 2017-03)
Background
Pharmacological inhibition of B cell receptor (BCR) signaling has recently emerged as an effective approach in a wide range of B lymphoid neoplasms. However, despite promising clinical activity ...
Porficenos para la fotoquimioterapia del cáncer y otras aplicaciones biomédicas
(Asociación de Químicos e Ingenieros del Instituto Químico de Sarrià, 2002)
La terapia fotodinámica (PDT) o fotoquimioterapia del cáncer es una modalidad terapéutica que consiste en la aplicación de compuestos fotosensibilizadores que se acumulan preferentemente en tejidos ...