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Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion
(Elsevier, 2021-06-25)
Fenitrothion is an organophosphorus insecticide usually found in aquatic ecosystems at concentrations in the range of low ng/L. In this manuscript we show that 24 h exposure to environmental concentrations ...
Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice
(Elsevier, 2022-07)
N-ethyl-pentedrone (NEPD, 2-(ethylamino)-1-phenyl-1-pentanone) is one of the latest synthetic cathinone derivatives that emerged into the illicit drug market. This drug has psychostimulant properties ...
Designing Polyelectrolyte Microneedles Based on Borylated Poly(β-aminoester) Polymers To Enhance Transdermal pH-Controlled Delivery of Nucleic Acids
(American Chemical Society, 2024-06-24)
The use of transdermal delivery for nucleic acidadministration is an interesting approach to overcoming limitations ofsystemic administration routes, such as first-pass effects, the painfulneedle ...
Extracellular vesicles and their current role in cancer immunotherapy
(MDPI, 2021-05-10)
Extracellular vesicles (EVs) are natural particles formed by the lipid bilayer and released from almost all cell types to the extracellular environment both under physiological conditions and in presence ...
Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP (“flakka”) Derivatives
(MDPI, 2022-02)
Changes in the molecular structure of synthetic cathinones has led to an increase in the number of novel emerging drugs in the illicit drug market at an unprecedented rate. Unfortunately, little is known ...
Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety
(Elsevier, 2020-11-18)
Glyphosate is the active ingredient of some of the most highly produced and used herbicides worldwide. The intensive applications of glyphosate-based herbicides and its half-life in water lead to its ...
Behavioural and neurochemical effects after repeated administration of N-ethylpentylone (ephylone) in mice
(Wiley, 2022)
N-ethyl-pentylone (NEP), also known as ‘ephylone’ and N-ethylnorpentylone, has been identified as one of the most recent novel psychostimulants to emerge into the illicit drug market and it has been ...
De-Novo Design of pre-miR-21 Maturation Inhibitors: Synthesis and Activity Assessment
(Wiley, 2023-07-14)
Targeting RNA with small molecules is a major challenge of current medicinal chemistry, and the identification and design of original scaffolds able to selectively interact with an RNA target remains ...
Pharmaceutical Residues in Senior Residences Wastewaters: High Loads, Emerging Risks
(MDPI, 2021-08-20)
Senior residences are health-care facilities that are socially-accepted for the assistance of elderly people. Since the elderly account for the foremost pharmaceutical-consuming age-group, senior ...
Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator
(eLife Sciences Publications, 2017-04)
Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive ...