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Photosensitizing proteins for antibacterial photodynamic inactivation
(Wiley-VCH Verlag, 2020-05)
We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their ...
Analysis of laccase‐like enzymes secreted by fungi isolatedfrom a cave in northern Spain
(Wiley, 2022-04)
Laccases belong to a family of multicopper enzymes able to oxidize a broad spectrum of organic compounds. Despite the well-known property of laccases to carry out bleaching and degradation of industrial ...
A machine learning approach to predict cellular uptake of pBAE polyplexes
(American Chemical Society, 2023-09)
The delivery of genetic material (DNA and RNA) to cells can cure a wide range of diseases but is limited by the delivery efficiency of the carrier system. Poly β-amino esters (pBAEs) are promising ...
Different mechanisms that promote protein monoubiquitination
(Asociación de Químicos e Ingenieros del Instituto Químico de Sarrià, 2015-04)
Protein monoubiquitination is a post-translational modification that consists of the conjugation of a single ubiquitin molecule to a target protein residue. Monoubiquitination regulates protein activity ...
Structural-functional analysis reveals a specific domain organization in family GH20 hexosaminidases
(Public Library of Science (PLoS), 2015-05)
Hexosaminidases are involved in important biological processes catalyzing the hydrolysis of N-acetyl-hexosaminyl residues in glycosaminoglycans and glycoconjugates. The GH20 enzymes present diverse ...
Synthesis, photophysical characterization and photoinduced antibacterial activity of methylene blue-loaded amino- and mannose-targeted mesoporous silica nanoparticles
(MDPI, 2015-04)
Over the last 20 years, the number of pathogenic multi-resistant microorganisms has grown steadily, which has stimulated the search for new strategies to combat antimicrobial resistance. Antimicrobial ...
Assessing amphiphilic ABAB Zn(II) Phthalocyanines with enhanced photosensitization abilities in In Vitro photodynamic therapy studies against cancer
(MDPI, 2020-01)
We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., ...
Structure-function features of a mycoplasma glycolipid synthase derived from structural data integration, molecular simulations, and mutational analysis
(Public Library of Science (PLoS), 2013-12)
Glycoglycerolipids are structural components of mycoplasma membranes with a fundamental role in membrane properties and stability. Their biosynthesis is mediated by glycosyltransferases (GT) that catalyze ...
Nanostructured AABB Zn (II) Phthalocyanines as Photodynamic Agents for Bacterial Inactivation
(Wiley, 2023-11)
In this work, the ability of amphiphilic Phthalocyanine (Pc) photosensitizers (PS) (Zn(II)Pcs PS1, PS2, and PS3) to assemble into cationic nanoparticles in water and to photo-inactivate bacterial strains ...
Charting the metabolic landscape of the facultative methylotroph bacillus methanolicus
(American Society for Microbiology, 2020-09)
Bacillus methanolicus MGA3 is a thermotolerant and relatively fast-growing methylotroph able to secrete large quantities of glutamate and lysine. These natural characteristics make B. methanolicus a ...