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Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles for the co-delivery of DOX/CPT-PEG for targeting HepG2 cells
(MDPI, 2020-11)
A pH-triggered mesoporous silica nanoparticle (MSN)-based nano-vehicle for the dual delivery of doxorubicin (DOX)/camptothecin-PEG (CPT-PEG) has been prepared. To enhance its selectivity, the nanoparticles ...
Electrostatic Coating of Viral Particles for Gene Delivery Applications in Muscular Dystrophies: Influence of Size on Stability and Antibody Protection
(IOS Press, 2021-09-14)
Background:Duchenne Muscular Dystrophy (DMD) is one of the most common muscular dystrophies, caused by mutated forms of the dystrophin gene. Currently, the only treatment available is symptoms management. ...
Zwitterionic 3D-printed non-immunogenic stealth microrobots
(Wiley, 2020-08)
Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a ...
Novel grafted electrochemical interface for covalent glucose oxidase immobilization using reactive pentafluorophenyl methacrylate
(Elsevier, 2018-12-01)
One of the most important factors for the proper functioning of enzymatic electrochemical biosensors is the enzyme immobilization strategy. In this work, glucose oxidase was covalently immobilized using ...
Determination of squalene by-products during model compound vulcanization studies by LC-ESI-MS using silver nitrate as a post-column reagent
(Asociación de Químicos e Ingenieros del Instituto Químico de Sarrià, 2014-01)
High Performance Liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI-MS) using silver nitrate as a post-column reagent has been used for the determination of squalene by-products ...
Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells
(Royal Society of Chemistry, 2020-07)
A switchable silane derived stimuli-responsive bottle-brush polyphosphazene (PPz) was prepared and attached to the surface of mesoporous silica nanoparticles (MSNs). The hybrid polymer with PEG-like ...
Bioactivity evaluation of commercial calcium phosphate-based bioceramics for bone regeneration
(Asociación de Químicos e Ingenieros del Instituto Químico de Sarrià, 2016-07)
Calcium phosphate-based bioceramics constitute a great promise for bone tissue engineering as they chemically resemble to mammalian bone and teeth. Their use is a viable alternative for bone regeneration ...
Nanomedicine in non-small cell lung cancer: from conventional treatments to immunotherapy
(MDPI, 2020-06)
Non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related mortality. The heterogeneous nature of this disease hinders its diagnosis and treatment, requiring continuous advances ...
Oligopeptide-modified poly(beta-amino ester)s-coated AdNuPARmE1A: boosting the efficacy of intravenously administered therapeutic adenoviruses
(Ivyspring International Publisher, 2020-02)
Oncolytic adenoviruses are used as agents for the treatment of cancer. However, their potential is limited due to the high seroprevalence of anti-adenovirus neutralizing antibodies (nAbs) within the ...
New developments in vertebroplasty materials
(Asociación de Químicos e Ingenieros del Instituto Químico de Sarrià, 2018-07)
Increasing life expectancy is leading to an increase in age-related diseases, like osteoporosis, which often involve the breakdown of bone. One of the main problems related with such disease is the ...