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Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father, and Child Cohort Study

Hernáez, Álvaro; Lee, Yunsung; Page, Christian Magnus; Skåra, Karoline Hansen; Håberg, Siri Eldevik; Magnus, Per; Njølstad, Pål R.; Andreassen, Ole A.; Corfield, Elizabeth C.; Havdahl, Alexandra; Fraser, Abigail; Burgess, Stephen; Lawlor, Deborah A.; Magnus, Maria Christine (Oxford University Press, 2023-11)

STUDY QUESTION Are impaired glucose tolerance (as measured by fasting glucose, glycated hemoglobin, and fasting insulin) and cardiovascular disease risk (as measured by low-density lipoprotein cholesterol, ...

Parental infertility and offspring cardiometabolic trajectories: a pooled analysis of three European cohorts

Hernáez, Álvaro; ElHakeem, Ahmed; Barros, Henrique; Vrijkotte, Tanja; Fraser, Abigail; Lawlor, Deborah A.; Magnus, Maria Christine (Elsevier, 2024-05)

Objective To assess whether parental infertility is associated with differences in cardiometabolic trajectories in offspring. Design Pooled observational analysis in three prospective cohorts. Set ...

Risk of cardiovascular disease in women and men with subfertility: the Trøndelag Health Study

Skåra, Karoline Hansen; Asvold, Bjørn O.; Hernáez, Álvaro; Fraser, Abigail; Rich-Edwards, Janet; Farland, Leslie; Næss, Øyvind; Lawlor, Deborah A.; Brumpton, Ben; Magnus, Maria Christine (Elsevier, 2022-07)

Objective: To investigate the association between subfertility and risk of cardiovascular disease (CVD) outcomes. Design: Prospective study. Setting: Population-based cohort. Patient(s): We studied ...

Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study

Hernáez, Álvaro; Wootton, Robyn E.; Page, Christian Magnus; Skåra, Karoline Hansen; Fraser, Abigail; Rogne, Tormod; Magnus, Per; Njølstad, Pål R.; Andreassen, Ole A.; Burgess, Stephen; Lawlor, Deborah A.; Magnus, Maria Christine (Elsevier, 2022-07)

Objective To investigate the association between smoking and infertility. Design Prospective study. Setting Nationwide cohort. Patients 28,606 women and 27,096 men with questionnaire and genotype ...

Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study

Hernáez, Álvaro; Rogne, Tormod; Skåra, Karoline Hansen; Håberg, Siri Eldevik; Page, Christian Magnus; Fraser, Abigail; Burgess, Stephen; Lawlor, Deborah A.; Magnus, Maria Christine (Oxford University Press, 2021-10)

STUDY QUESTION What is the association between BMI and subfertility? SUMMARY ANSWER We observed a J-shaped relationship between BMI and subfertility in both sexes, when using both a standard ...

Cardiovascular disease risk factors and infertility: multivariable analyses and one-sample Mendelian randomization analyses in the Trøndelag Health Study

Skåra, Karoline Hansen; Hernáez, Álvaro; Næss, Øyvind; Fraser, Abigail; Lawlor, Deborah A.; Burgess, Stephen; Brumpton, Ben; Magnus, Maria Christine (Oxford University Press, 2024-05)

STUDY QUESTION Are cardiovascular disease (CVD) risk factors causally associated with higher risk of infertility among women and men? SUMMARY ANSWER We found evidence to support a causal relationship ...