Browsing by Author "Fornaguera Puigvert, Cristina"
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Application of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas
Fornaguera Puigvert, Cristina; Lázaro, Miguel Ángel; Brugada Vilà, Pau; Porcar, Irene; Morera, Ingrid; Guerra Rebollo, Marta; Garrido, Cristina; Blanco, Jeronimo; Cascante, Anna; Borrós i Gómez, Salvador (Drug Delivery, 2018-02-07)Glioblastoma multiforme (GBM) is the most devastating primary brain tumor due to its infiltrating and diffuse growth characteristics, a situation compounded by the lack of effective treatments. Currently, ... -
Biomineralization in Three-Dimensional Scaffolds Based on Bacterial Nanocellulose for Bone Tissue Engineering: Feature Characterization and Stem Cell Differentiation
Cañas Gutiérrez, Ana; Toro, Lenka; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador; Osorio, Marlon; Castro Herazo, Cristina; Arboleda Toro, David (Polymers 2023, 15(9), 2012, 2023-05)Bacterial nanocellulose (BNC) has a negative surface charge in physiological environments, which allows the adsorption of calcium ions to initiate the nucleation of different calcium phosphate phases. ... -
Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy
Riera, Roger; Tauler, Jana; Feiner Gracia, Natàlia; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina; Albertazzi, Lorenzo (ChemMedChem 2022, 17(13), e202100633, 2022)Nanomedicine emerged some decades ago with the hope to be the solution for most unmet medical needs. However, tracking materials at nanoscale is challenging to their reduced size, below the resolution ... -
Designing Polyelectrolyte Microneedles Based on Borylated Poly(β-aminoester) Polymers To Enhance Transdermal pH-Controlled Delivery of Nucleic Acids
González-Sáenz, Patricia; Cosialls, Raúl; Texidó, Robert; Dols-Perez, Aurora; Cuenca, Ana B.; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina (ACS Applied Polymer Materials 2024;6(15):8842-8855, 2024-06-24)The use of transdermal delivery for nucleic acidadministration is an interesting approach to overcoming limitations ofsystemic administration routes, such as first-pass effects, the painfulneedle ... -
Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells
Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador; Salinas, Yolanda; Kneidinger, Michael; Bruggemann, Oliver; Teasdale, Ian (RSC Advances. Vol.10, n.46 (2020), p.27305-27314, 2020-07)A switchable silane derived stimuli-responsive bottle-brush polyphosphazene (PPz) was prepared and attached to the surface of mesoporous silica nanoparticles (MSNs). The hybrid polymer with PEG-like ... -
Effect of surface functionalization and loading on the mechanical properties of soft polymeric nanoparticles prepared by nano-emulsion templating
Dols-Perez, Aurora; Fornaguera Puigvert, Cristina; Feiner Gracia, Natalia; Grijalvo, Santiago; Solans, Conxita; Gomila, Gabriel (Colloids and Surfaces B: Biointerfaces 2023, 222, 113019, 2023-02)Drug and gene delivery systems based on polymeric nanoparticles offer a greater efficacy and a reduced toxicity compared to traditional formulations. Recent studies have evidenced that their internalization, ... -
Efficient extracellular vesicles freeze-dry method for direct formulations preparation and use
Guarro, Mònica; Suñer, Francisca; Lecina i Veciana, Martí; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina (Colloids and Surfaces B: Biointerfaces, 2022-07-31)Despite the great knowledge achieved in the field of extracellular vesicles (EVs), the short lifetime of EVs liquid formulation still hampers the transfer of EVs technology to clinical applications. In ... -
Electrostatic Coating of Viral Particles for Gene Delivery Applications in Muscular Dystrophies: Influence of Size on Stability and Antibody Protection
Guerra Rebollo, Marta; Stampa, María; Lázaro, Miguel Ángel; Cascante, Anna; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador (Journal of Neuromuscular Diseases, vol. 8, no. 5, pp. 815-825, 2021-09-14)Background:Duchenne Muscular Dystrophy (DMD) is one of the most common muscular dystrophies, caused by mutated forms of the dystrophin gene. Currently, the only treatment available is symptoms management. ... -
Extracellular vesicles and their current role in cancer immunotherapy
Giacobino, Carla; Canta, Marta; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador; Cauda, Valentina (Cancers, 2021-05-10)Extracellular vesicles (EVs) are natural particles formed by the lipid bilayer and released from almost all cell types to the extracellular environment both under physiological conditions and in presence ... -
Fine-tuning formulation and biological interaction of doxorubicin-loaded polymeric nanoparticles via electrolyte concentration modulation
Bofill Bonet, Carles; Gil Vives, Maria; Artigues Cladera, Margalida; Hernández Hernández, Marta; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina (Journal of Molecular Liquids, 2023, vol. 390, part A, 122986, 2023-09)Doxorubicin (DOX) is amongst the most widely used chemotherapeutic drugs against various cancers. However, its controlled biodistribution to the tumor site at the required pharmacokinetics profile ... -
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles for the co-delivery of DOX/CPT-PEG for targeting HepG2 cells
Sánchez García, David; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina; Martínez Edo, Gabriel (Pharmaceutics. Vol.12, n.11 (2020), 1048, 2020-11)A pH-triggered mesoporous silica nanoparticle (MSN)-based nano-vehicle for the dual delivery of doxorubicin (DOX)/camptothecin-PEG (CPT-PEG) has been prepared. To enhance its selectivity, the nanoparticles ... -
Liver-targeted nanoparticles delivering nitric oxide reduce portal hypertension in cirrhotic rats
Perramón Corominas, Meritxell; Navalón López, María; Fernández Varo, Guillermo; Moreno Lanceta, Alazne; García Jiménez, Rocío; Faneca Farrés, Joana; López-Moya, Mario; Fornaguera Puigvert, Cristina; García-Villoria, Judith; Morales-Ruiz, Manuel; Melgar Lesmes, Pedro; Borrós i Gómez, Salvador; Jiménez, Wladimiro (2024-01-13)Nitric oxide (NO) is a small vasodilator playing a key role in the pathogenesis of portal hypertension. Here, we assessed the potential therapeutic effect of a NO donor targeted to the liver by ... -
Nanomedicine in non-small cell lung cancer: from conventional treatments to immunotherapy
Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador; García-Fernández, Coral (Cancers. Vol.12, n.6 (2020), 1609, 2020-06)Non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related mortality. The heterogeneous nature of this disease hinders its diagnosis and treatment, requiring continuous advances ... -
Novel α-mannose-functionalized poly(β-amino ester) nanoparticles as mRNA vaccines with increased antigen presenting cell selectivity in the spleen
González-Ríos, Nil; Artigues Cladera, Margalida; Guerra Rebollo, Marta; Planas, Antoni (Planas Sauter); Borrós i Gómez, Salvador; Faijes, Magda; Fornaguera Puigvert, Cristina (Journal of Materials Chemistry B, 2023-06-14)mRNA vaccination has emerged as a prominent therapy for the future of medicine. Despite the colossal advance in this technology and worldwide efficacy proof (ca. COVID vaccines), mRNA carriers still ... -
Nucleic acid-loaded poly(beta-aminoester) nanoparticles for cancer nano-immuno therapeutics
Magaña Rodriguez, J. Rodrigo; Guerra Rebollo, Marta; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina (Drug Delivery and Translational Research. 2024;14:3477–3493, 2024-05-03)Immunotherapy has emerged as a promising approach to cancer treatment, offering improved survival rates and enhanced patients’ quality of life. However, realizing the full potential of immunotherapy in ... -
Oligopeptide-modified poly(beta-amino ester)s-coated AdNuPARmE1A: boosting the efficacy of intravenously administered therapeutic adenoviruses
Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina; Brugada Vilà, Pau; Fillat i Fonts, Cristina; Cascante, Anna; Lázaro, Miguel Ángel; Castells-Sala, Cristina; Rovira-Rigau, Maria; Albertazzi, Lorenzo (Theranostics. Vol.10, n.6 (2020), p. 2744-2758, 2020-02)Oncolytic adenoviruses are used as agents for the treatment of cancer. However, their potential is limited due to the high seroprevalence of anti-adenovirus neutralizing antibodies (nAbs) within the ... -
Role of Survivin in Bladder Cancer: Issues to Be Overcome When Designing an Efficient Dual Nano-Therapy
Arista Romero, Maria; Cascante, Anna; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador (Pharmaceutics, 2021-11-19)Bladder cancer is the 10th most diagnosed cancer, with almost 10 M cancer deaths last year worldwide. Currently, chemotherapy is widely used as adjuvant therapy after surgical transurethral resection. ... -
Unravelling the role of individual components in pBAE/polynucleotide polyplexes in the synthesis of tailored carriers for specific applications: on the road to rational formulations
Navalón López, María; Dols-Perez, Aurora; Grijalvo, Santiago; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador (Nanoscale Advances 2023, 7 (6), 2023-03)Oligopeptide end–modified poly(β-amino ester)s (OM-pBAEs) offer a means for the effective implementation of gene therapeutics in the near future. A fine-tuning of OM-pBAEs to meet application requirements ...