Browsing by Author "Borrós i Gómez, Salvador"
Now showing items 1-20 of 46
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A machine learning approach to predict cellular uptake of pBAE polyplexes
Loecher, Aparna; Bruyns-Haylett, Michael; Ballester, Pedro J.; Borrós i Gómez, Salvador; Oliva, Núria (Biomaterials Science 2023, 12(17), 5697-6002, 2023-09)The delivery of genetic material (DNA and RNA) to cells can cure a wide range of diseases but is limited by the delivery efficiency of the carrier system. Poly β-amino esters (pBAEs) are promising ... -
A new four-point probe design to measure conductivity in polymeric thin films
Yagüe Marrón, Jose Luis; Guimerà, A.; Villa, Rosa; Agulló Chaler, Núria; Borrós i Gómez, Salvador (Afinidad LXX, 563, Julio - Septiembre 2013, 2013-07)En el desarrollo de nuevas aplicaciones de polímeros conductores, la medida de forma precisa de la conductividad es todavía un reto, especialmente para muestras muy delgadas como los obtenidos por CVD. ... -
Analytical parameters of a novel glucose biosensor based on grafted PFM as a covalent immobilization technique
Artigues Cladera, Margalida; Gilabert-Porres, Joan; Texidó Bartes, Robert; Borrós i Gómez, Salvador; Abellà, Jordi (Abellà i Iglesias); Colominas Fuster, Sergi (Sensors, 2021-06-15)Bioanalytical methods, in particular electrochemical biosensors, are increasingly used in different industrial sectors due to their simplicity, low cost, and fast response. However, to be able to reliably ... -
Application of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas
Fornaguera Puigvert, Cristina; Lázaro, Miguel Ángel; Brugada Vilà, Pau; Porcar, Irene; Morera, Ingrid; Guerra Rebollo, Marta; Garrido, Cristina; Blanco, Jeronimo; Cascante, Anna; Borrós i Gómez, Salvador (Drug Delivery, 2018-02-07)Glioblastoma multiforme (GBM) is the most devastating primary brain tumor due to its infiltrating and diffuse growth characteristics, a situation compounded by the lack of effective treatments. Currently, ... -
Bacteriophobic Zwitterionic/Dopamine Coatings for Medical Elastomers
Texidó, Robert; Cabanach, Pol; Kaplan, Richard; García Bonillo, Cristina; Pérez, Darío; Zhang, Shuo; Borrós i Gómez, Salvador; Pena-Francesch, Abdon (Advanced Materials Interfaces, 2022, 9(30), 2201152, 2022)Despite modern advancements in sterilization and medical practices, bacterial infections remain a significant concern in the implantation of medical devices. There is currently an urgent need for ... -
Bioactivity evaluation of commercial calcium phosphate-based bioceramics for bone regeneration
Borrós i Gómez, Salvador; Mas, A. (Afinidad. Vol.73, n.575 (2016), p.170-174, 2016-07)Calcium phosphate-based bioceramics constitute a great promise for bone tissue engineering as they chemically resemble to mammalian bone and teeth. Their use is a viable alternative for bone regeneration ... -
Biomineralization in Three-Dimensional Scaffolds Based on Bacterial Nanocellulose for Bone Tissue Engineering: Feature Characterization and Stem Cell Differentiation
Cañas Gutiérrez, Ana; Toro, Lenka; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador; Osorio, Marlon; Castro Herazo, Cristina; Arboleda Toro, David (Polymers 2023, 15(9), 2012, 2023-05)Bacterial nanocellulose (BNC) has a negative surface charge in physiological environments, which allows the adsorption of calcium ions to initiate the nucleation of different calcium phosphate phases. ... -
Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy
Riera, Roger; Tauler, Jana; Feiner Gracia, Natàlia; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina; Albertazzi, Lorenzo (ChemMedChem 2022, 17(13), e202100633, 2022)Nanomedicine emerged some decades ago with the hope to be the solution for most unmet medical needs. However, tracking materials at nanoscale is challenging to their reduced size, below the resolution ... -
CRISPR/Cas9-Mediated Knockin Application in Cell Therapy: A Non-viral Procedure for Bystander Treatment of Glioma in Mice
Meca Cortés, Oscar; Guerra Rebollo, Marta; Garrido, Cristina; Borrós i Gómez, Salvador; Rubio, Nuria; Blanco, Jeronimo (Molecular Therapy: Nucleic Acids, 2017-07-26)The use of non-viral procedures, together with CRISPR/Cas9 genome-editing technology, allows the insertion of single-copy therapeutic genes at pre-determined genomic sites, overcoming safety limitations ... -
Designing Polyelectrolyte Microneedles Based on Borylated Poly(β-aminoester) Polymers To Enhance Transdermal pH-Controlled Delivery of Nucleic Acids
González-Sáenz, Patricia; Cosialls, Raúl; Texidó, Robert; Dols-Perez, Aurora; Cuenca, Ana B.; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina (ACS Applied Polymer Materials 2024;6(15):8842-8855, 2024-06-24)The use of transdermal delivery for nucleic acidadministration is an interesting approach to overcoming limitations ofsystemic administration routes, such as first-pass effects, the painfulneedle ... -
Detection of peptide-based nanoparticles in blood plasma by ELISA
Borrós i Gómez, Salvador; Bode, Gerard H.; Pickl, Karin E.; Sánchez Purrà, Maria; Albaiges, Berta; Pötgens, Andy J. G.; Schmitz, Christoph; Sinner, Frank M.; Losen, Mario; Steinbusch, Harry W. M.; Frank, Hans-Georg; Martinez-Martinez, Pilar (PLoS ONE. Vol.10, n.5 (2015), e0126136, 2015-05)Aims The aim of the current study was to develop a method to detect peptide-linked nanoparticles in blood plasma. Materials & Methods A convenient enzyme linked immunosorbent assay (ELISA) was developed ... -
Determination of squalene by-products during model compound vulcanization studies by LC-ESI-MS using silver nitrate as a post-column reagent
Agulló Chaler, Núria; Comellas Riera, Lluís; Borrós i Gómez, Salvador; Vega Sánchez, Berta; Ventura Benítez, Meritxell (Afinidad LXXI, 565, Enero - Marzo 2014, 2014-01)High Performance Liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI-MS) using silver nitrate as a post-column reagent has been used for the determination of squalene by-products ... -
Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells
Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador; Salinas, Yolanda; Kneidinger, Michael; Bruggemann, Oliver; Teasdale, Ian (RSC Advances. Vol.10, n.46 (2020), p.27305-27314, 2020-07)A switchable silane derived stimuli-responsive bottle-brush polyphosphazene (PPz) was prepared and attached to the surface of mesoporous silica nanoparticles (MSNs). The hybrid polymer with PEG-like ... -
Efficient extracellular vesicles freeze-dry method for direct formulations preparation and use
Guarro, Mònica; Suñer, Francisca; Lecina i Veciana, Martí; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina (Colloids and Surfaces B: Biointerfaces, 2022-07-31)Despite the great knowledge achieved in the field of extracellular vesicles (EVs), the short lifetime of EVs liquid formulation still hampers the transfer of EVs technology to clinical applications. In ... -
Electrochemical impedance spectroscopy evaluation of nonthermal plasma restoration for ductile metals in cultural heritage artifacts
Giménez Barrera, Patricia; Colominas Fuster, Sergi; Borrós i Gómez, Salvador (Plasma Processes and Polymers 2023, 20 (4), 2200136, 2023-04)Despite the large number of studies devoted to understanding the degradation process of ductile metals in cultural heritage, there is still a lack of consolidated protocols for their restoration. ... -
Electrostatic Coating of Viral Particles for Gene Delivery Applications in Muscular Dystrophies: Influence of Size on Stability and Antibody Protection
Guerra Rebollo, Marta; Stampa, María; Lázaro, Miguel Ángel; Cascante, Anna; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador (Journal of Neuromuscular Diseases, vol. 8, no. 5, pp. 815-825, 2021-09-14)Background:Duchenne Muscular Dystrophy (DMD) is one of the most common muscular dystrophies, caused by mutated forms of the dystrophin gene. Currently, the only treatment available is symptoms management. ... -
Ex-vivo mechanical sealing properties and toxicity of a bioadhesive patch as sealing system for fetal membrane iatrogenic defects
Borrós i Gómez, Salvador; Febas, Germán; Micheletti, Talita; Eixarch, Elisenda; Berdun, Sergio; Mazza, Edoardo; Gratacos, Eduard (Scientific Reports. Vol.10, n.1 (2020), 18608, 2020-10)Preterm prelabor rupture of membranes (PPROM) is the most frequent complication of fetal surgery. Strategies to seal the membrane defect created by fetoscopy aiming to reduce the occurrence of PPROM ... -
Extracellular vesicles and their current role in cancer immunotherapy
Giacobino, Carla; Canta, Marta; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador; Cauda, Valentina (Cancers, 2021-05-10)Extracellular vesicles (EVs) are natural particles formed by the lipid bilayer and released from almost all cell types to the extracellular environment both under physiological conditions and in presence ... -
Fine-tuning formulation and biological interaction of doxorubicin-loaded polymeric nanoparticles via electrolyte concentration modulation
Bofill Bonet, Carles; Gil Vives, Maria; Artigues Cladera, Margalida; Hernández Hernández, Marta; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina (Journal of Molecular Liquids, 2023, vol. 390, part A, 122986, 2023-09)Doxorubicin (DOX) is amongst the most widely used chemotherapeutic drugs against various cancers. However, its controlled biodistribution to the tumor site at the required pharmacokinetics profile ... -
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles for the co-delivery of DOX/CPT-PEG for targeting HepG2 cells
Sánchez García, David; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina; Martínez Edo, Gabriel (Pharmaceutics. Vol.12, n.11 (2020), 1048, 2020-11)A pH-triggered mesoporous silica nanoparticle (MSN)-based nano-vehicle for the dual delivery of doxorubicin (DOX)/camptothecin-PEG (CPT-PEG) has been prepared. To enhance its selectivity, the nanoparticles ...