Browsing by Author "Biarnés Fontal, Xevi"
Now showing items 1-12 of 12
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1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs
Bosch-Sanz, Oriol; Rabadà, Yvette; Biarnés Fontal, Xevi; Pedreño, Javier; Caveda, Luis; Balcells Camps, Mercedes; Martorell López, Jordi; Sánchez García, David (International Journal of Molecular Sciences, 23(23), 2022, 14942, 2022)Fibrinolysis is a natural process that ensures blood fluidity through the removal of fibrin deposits. However, excessive fibrinolytic activity can lead to complications in different circumstances, such ... -
Binding of common organic UV-filters to the thyroid hormone transport protein transthyretin using in vitro and in silico studies: Potential implications in health.
Cotrina, Ellen Y.; Oliveira, Angela; Llop, Jordi; Quintana, Jordi; Biarnés Fontal, Xevi; Cardoso, Isabel; Díaz Cruz, M. Silvia; Arsequell, Gemma (Environmental Research 2023, 217, 114836, 2023-01-15)Several anthropogenic contaminants have been identified as competing with the thyroid hormone thyroxine (T4) for binding to transport proteins as transthyretin (TTR). This binding can potentially create ... -
Comparison of two peroxidases with high potential for biotechnology applications – HRP vs. APEX2
Biarnés Fontal, Xevi; Škulj, Sanja; Kožić, Matej; Barišić, Antun; Vega, Aitor; Piantanida, Ivo; Barisic, Ivan; Bertoša, Branimir (Computational and structural biotechnology journal. 2024,23:742-751, 2024-01-12)Peroxidases are essential elements in many biotechnological applications. An especially interesting concept involves split enzymes, where the enzyme is separated into two smaller and inactive proteins ... -
Control of Substrate Conformation by Hydrogen Bonding in a Retaining β-Endoglycosidase
Nin-Hill, Alba; Ardevol, Albert; Biarnés Fontal, Xevi; Planas, Antoni (Planas Sauter); Rovira, Carme (Chemistry - A European Journal 2023, 29(70), e202302555, 2023-12-14)Bacterial β-glycosidases are hydrolytic enzymes that depolymerize polysaccharides such as β-cellulose, β-glucans and β-xylans from different sources, offering diverse biomedical and industrial uses. It ... -
Enzymatic Hydrolysis of Human Milk Oligosaccharides. The Molecular Mechanism of Bifidobacterium Bifidum Lacto-N-biosidase
Cuxart, Irene; Coines, Joan; Esquivias, Oriol; Faijes, Magda; Planas, Antoni (Planas Sauter); Biarnés Fontal, Xevi; Rovira, Carme (ACS Catalysis 2022, 12(8), 4737–4743, 2022)Bifidobacterium bifidum lacto-N-biosidase (LnbB) is a critical enzyme for the degradation of human milk oligosaccharides in the gut microbiota of breast-fed infants. Guided by recent crystal structures, ... -
Enzymatic production of defined chitosan oligomers with a specific pattern of acetylation using a combination of chitin oligosaccharide deacetylases
Planas, Antoni (Planas Sauter); Biarnés Fontal, Xevi; Hamer, Stefanie Nicole; Cord-Landwehr, Stefan; Waegeman, Hendrik; Moerschbacher, Bruno Maria; Kolkenbrock, Stephan (Scientific Reports. Vol.5, 8716 (2015), 2015-03)Chitin and chitosan oligomers have diverse biological activities with potentially valuable applications in fields like medicine, cosmetics, or agriculture. These properties may depend not only on the ... -
Expanding the chitin oligosaccharide portfolio by engineering NodC chitin synthases in Escherichia coli
Guidi, Chiara; Biarnés Fontal, Xevi; Planas, Antoni (Planas Sauter); De Mey, Marjan (Current Research in Biotechnology. 2024;8:100255, 2024-09-17)Synthetic biology greatly accelerated the building process of potential microbial cell factories for the production of industrially relevant compounds, e.g., chitooligosaccharides (COS) which have an ... -
Integrative structure determination reveals functional global flexibility for an ultra-multimodular arabinanase
Lansky, Shifra; Salama, Rachel; Biarnés Fontal, Xevi; Shwartstein, Omer; Schneidman-Duhovny, Dina; Planas, Antoni (Planas Sauter); Shoham, Yuval; Shoham, Gil (Communications Biology 2022, 5, 465, 2022)AbnA is an extracellular GH43 α-L-arabinanase from Geobacillus stearothermophilus, a key bacterial enzyme in the degradation and utilization of arabinan. We present herein its full-length crystal ... -
Structural-functional analysis reveals a specific domain organization in family GH20 hexosaminidases
Faijes, Magda; Val Cid, Cristina; Biarnés Fontal, Xevi; Planas, Antoni (Planas Sauter) (PLoS ONE. Vol.10, n.5 (2015), e0128075, 2015-05)Hexosaminidases are involved in important biological processes catalyzing the hydrolysis of N-acetyl-hexosaminyl residues in glycosaminoglycans and glycoconjugates. The GH20 enzymes present diverse ... -
Structure-function features of a mycoplasma glycolipid synthase derived from structural data integration, molecular simulations, and mutational analysis
Planas, Antoni (Planas Sauter); Biarnés Fontal, Xevi; Romero, Javier (Romero García); Francisco, Carles (PLoS One. Vol.8, n.12 (2013), e81990, 2013-12)Glycoglycerolipids are structural components of mycoplasma membranes with a fundamental role in membrane properties and stability. Their biosynthesis is mediated by glycosyltransferases (GT) that catalyze ... -
Substrate distortion in the Michaelis complex of Bacillus 1,3–1,4-β-glucanase: insight from first principles molecular dynamics simulations
Planas, Antoni (Planas Sauter); Biarnés Fontal, Xevi; Nieto, Joan; Rovira i Virgili, Carme (Journal of Biological Chemistry. Vol.281, n.3 (2006), p.1432–1441, 2006-01)The structure and dynamics of the enzyme-substrate complex of Bacillus 1,3–1,4-β-glucanase, one of the most active glycoside hydrolases, is investigated by means of Car-Parrinello molecular dynamics ... -
Unravelling the Antifibrinolytic Mechanism of Action of the 1,2,3-Triazole Derivatives
Rabadà, Yvette; Bosch-Sanz, Oriol; Biarnés Fontal, Xevi; Pedreño, Javier; Caveda, Luis; Sánchez García, David; Martorell López, Jordi; Balcells Camps, Mercedes (International Journal of Molecular Sciences. 2024;25(13):7002, 2024-06-26)A new family of antifibrinolytic drugs has been recently discovered, combining a triazole moiety, an oxadiazolone, and a terminal amine. Two of the molecules of this family have shown activity that is ...