Now showing items 1-13 of 13

    • 1,6-Naphthyridin-2(1H)-ones: Synthesis and Biomedical Applications 

      Oliveras, Juan Marcos; Puig de la Bellacasa Cazorla, Raimon; Estrada Tejedor, Roger; Teixidó i Closa, Jordi; Borrell Bilbao, José Ignacio (Pharmaceuticals 2021;14(10):1029, 2021-10-09)
      Naphthyridines, also known as diazanaphthalenes, are a group of heterocyclic compounds that include six isomeric bicyclic systems containing two pyridine rings. 1,6-Naphthyridines are one of the members ...
    • 1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications 

      Donaire-Arias, Ana; Montagut, Ana Maria; Puig de la Bellacasa Cazorla, Raimon; Teixidó i Closa, Jordi; Borrell Bilbao, José Ignacio (Molecules 27(7), 2022, 2237, 2022)
      Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which ...
    • Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma 

      Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Puig de la Bellacasa Cazorla, Raimon; Roué, Gaël; Balsas, P.; Esteve-Arenys, A.; Roldán, J.; Jiménez, L.; Rodríguez, V.; Valero, J. G.; Chamorro-Jorganes, A.; Matas-Céspedes, A.; Moros, A.; Martínez, A.; Campo, E.; Sáez-Borderías, A.; Pérez-Galán, P.; Colomer, D. (Journal of Hematology & Oncology. Vol.10, n.80 (2017), 2017-03)
      Background Pharmacological inhibition of B cell receptor (BCR) signaling has recently emerged as an effective approach in a wide range of B lymphoid neoplasms. However, despite promising clinical activity ...
    • Applying Molecular Modeling to the Design of Innovative, Non-Symmetrical CXCR4 Inhibitors with Potent Anticancer Activity 

      Martínez-Asensio, Miquel; Sàrrias, Lluís; Gorjón de Pablo, Gema; Fernández-Serrano, Miranda; Camaló Vila, Judith; Puig de la Bellacasa Cazorla, Raimon; Teixidó i Closa, Jordi; Roué, Gaël; Borrell Bilbao, José Ignacio; Estrada Tejedor, Roger; Gibert Bosch, Albert (International Journal of Molecular Sciences. 2024;25(17):9446, 2024-08-28)
      The identification of new compounds with potential activity against CXC chemokine receptor type 4 (CXCR4) has been broadly studied, implying several chemical families, particularly AMD3100 derivatives. ...
    • Autocatalytic photoinduced oxidative dehydrogenation of pyrido[2,3-d]pyrimidin-7(8H)-ones: synthesis of C5–C6 unsaturated systems with concomitant formation of a long-lived radical 

      de Rocafiguera, Claudi; Lloveras, Vega; Vidal Gancedo, José; Teixidó i Closa, Jordi; Estrada Tejedor, Roger; Borrell Bilbao, José Ignacio; Puig de la Bellacasa Cazorla, Raimon (Organic Chemistry Frontiers, 2024, 11(1), 2024-01-07)
      5,6-Dihydropyrido[2,3-d]pyrimidin-7(8H)-ones are readily accessed by a variety of methods and are a good scaffold for the development of biologically active compounds. However, they are very reluctant ...
    • Deconstructing Markush: Improving the R&D Efficiency Using Library Selection in Early Drug Discovery 

      Manen Freixa, Leticia; Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Estrada Tejedor, Roger (Pharmaceuticals 2022, 15(9), 1159, 2022)
      Most of the product patents claim a large number of compounds based on a Markush structure. However, the identification and optimization of new principal active ingredients is frequently driven by a ...
    • Expanding the Diversity at the C-4 Position of Pyrido[2,3-d]pyrimidin-7(8H)-ones to Achieve Biological Activity against ZAP-70 

      Masip, Victor; Lirio, Ángel; Sánchez-López, Albert; Cuenca, Ana B.; Puig de la Bellacasa Cazorla, Raimon; Abrisqueta, Pau; Teixidó i Closa, Jordi; Borrell Bilbao, José Ignacio; Gibert, Albert; Estrada Tejedor, Roger (Pharmaceuticals 2021;14(12):1311, 2021-12-15)
      Pyrido[2,3-d]pyrimidin-7(8H)-ones have attracted widespread interest due to their similarity with nitrogenous bases found in DNA and RNA and their potential applicability as tyrosine kinase inhibitors. ...
    • Heteroacoplamientos catalizados por paladio 

      Teixidó i Closa, Jordi; Sánchez García, David; Borrós i Gómez, Salvador; Nonell, Santi; Borrell Bilbao, José Ignacio; Colominas Guàrdia, Carles (Afinidad. Vol.59, n.500 (2002), p.325-336, 2002)
      Durante los diez últimos años la química del paladio se ha aplicado intensamente en síntesis orgánica debido a su versatilidad y a su gran selectividad. En esta breve revisión se muestran las características ...
    • In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models 

      Estrada Tejedor, Roger; Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; González, Àlex L.; Konieczn, Piotr; Llamusi, Beatriz; Delgado-Pinar, Estefanía; Garcia-España, Enrique; Pérez-Alonso, Manuel; Artero, Ruben (PLoS ONE. Vol.12, n.6 (2017), e0178931, 2017-06)
      Myotonic dystrophy type 1 (DM1) is a rare multisystemic disorder associated with an expansion of CUG repeats in mutant DMPK (dystrophia myotonica protein kinase) transcripts; the main effect of these ...
    • Introducción a la química combinatoria 

      Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Falcó, José Luis; Pascual, Rosalía (Afinidad. Vol.59, n.500 (2002), p.314-324, 2002)
      Durante los últimos diez años la Química Combinatoria se ha convertido en una técnica usual para el descubrimiento y desarrollo de nuevos productos con actividad biológica. El presente minireview pretende ...
    • Multiscale modeling for complex chemical systems: highlights about the Nobel Prize in Chemistry 2013 

      Estrada Tejedor, Roger; Ros Blanco, Laia; Teixidó i Closa, Jordi (Afinidad. Vol.71, n.566 (2014), p.89-94, 2014-04)
      The Nobel Prize in Chemistry 2013 was awarded jointly to Martin Karplus, Michael Levitt and Arieh Warshel for the development of multiscale models for complex chemical systems. From the simplest ...
    • Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors 

      Borrell Bilbao, José Ignacio; Puig de la Bellacasa Cazorla, Raimon; Gibert Bosch, Albert; Planesas, Jesús M.; Ros Blanco, Laia; Batllori Aguilà, Xavier; Badía, Roger; Clotet i Sala, Bonaventura; Esté, José A.; Teixidó i Closa, Jordi (Organic & Biomolecular Chemistry. Vol.14, n.4 (2016), p.1455-1472, 2015-12)
      The paradigm, derived from bicyclams and other cyclams, by which it is necessary to use the p-phenylene moiety as the central core in order to achieve high HIV-1 antiviral activities has been reexamined ...
    • Porficenos para la fotoquimioterapia del cáncer y otras aplicaciones biomédicas 

      Nonell, Santi; Sánchez García, David; Borrell Bilbao, José Ignacio; Teixidó i Closa, Jordi; Arad, Ofir; Gavaldá, Ana; Rey, Óscar; Rubio, Noemi; Cañete, Magdalena; Juarranz, Ángeles; Villanueva, Ángeles; Stockert, Juan Carlos; Díaz Jiménez, Pablo J. (Afinidad. Vol.59, n.500 (2002), p.343-356, 2002)
      La terapia fotodinámica (PDT) o fotoquimioterapia del cáncer es una modalidad terapéutica que consiste en la aplicación de compuestos fotosensibilizadores que se acumulan preferentemente en tejidos ...