Browsing by Author "Cairó, Jordi Joan"
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A simplified implementation of the stationary liquid mass balance method for on‐line OUR monitoring in animal cell cultures
Lecina i Veciana, Martí; Fontova i Sosa, Andreu Francesc; López Repullo, Jonatan; Martínez-Monge, Iván; Comas Sánchez, Pere; Bragós Bardia, Ramon; Cairó, Jordi Joan (Journal of Chemical Technology and Biotechnology. Vol.93, n.6 (2018), p.1757-1766, 2018-05)BACKGROUND Compared with other methods, the stationary liquid mass balance method for oxygen uptake rate (OUR) determination offers advantages in terms of estimation accuracy and reduction of stress. ... -
Metabolic flux balance analysis during lactate and glucose concomitant consumption in HEK293 cell cultures
Martínez-Monge, Iván; Albiol, Joan; Lecina i Veciana, Martí; Liste Calleja, Leticia; Miret, Joan; Solà, Carles; Cairó, Jordi Joan (Biotechnology and Bioengineering, 2018-10-26)At early stages of the exponential growth phase in HEK293 cell cultures, the tricarboxylic acid cycle is unable to process all the amount of NADH generated in the glycolysis pathway, being lactate the ... -
Monitoring Tools for the Development of High Cell Density Culture Strategies
Lecina i Veciana, Martí; Comas Sánchez, Pere; Martínez-Monge, Iván; Cairó, Jordi Joan (Cell Culture Engineering and Technology. Cell Engineering, 2022-02-20)Biopharmaceuticals market has been constantly increasing during the last years, what is transforming the manufacturing industry of biomolecules. The efforts have been put into better understanding how ... -
The Effect of the Expression of the Antiapoptotic BHRF1 Gene on the Metabolic Behavior of a Hybridoma Cell Line
Martínez-Monge, Iván; Comas Sánchez, Pere; Catalán-Tatjer, David; Prat, Jordi; Casablancas, Antoni; Paredes, Carlos J.; Lecina i Veciana, Martí; Cairó, Jordi Joan (Applied Sciences, 2021-07-06)One of the most important limitations of mammalian cells-based bioprocesses, and particularly hybridoma cell lines, is the accelerated metabolism related to glucose and glutamine consumption. The high ...