Browsing by Author "Lázaro, Miguel Ángel"
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Application of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas
Fornaguera Puigvert, Cristina; Lázaro, Miguel Ángel; Brugada Vilà, Pau; Porcar, Irene; Morera, Ingrid; Guerra Rebollo, Marta; Garrido, Cristina; Blanco, Jeronimo; Cascante, Anna; Borrós i Gómez, Salvador (Drug Delivery, 2018-02-07)Glioblastoma multiforme (GBM) is the most devastating primary brain tumor due to its infiltrating and diffuse growth characteristics, a situation compounded by the lack of effective treatments. Currently, ... -
Electrostatic Coating of Viral Particles for Gene Delivery Applications in Muscular Dystrophies: Influence of Size on Stability and Antibody Protection
Guerra Rebollo, Marta; Stampa, María; Lázaro, Miguel Ángel; Cascante, Anna; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador (Journal of Neuromuscular Diseases, vol. 8, no. 5, pp. 815-825, 2021-09-14)Background:Duchenne Muscular Dystrophy (DMD) is one of the most common muscular dystrophies, caused by mutated forms of the dystrophin gene. Currently, the only treatment available is symptoms management. ... -
Oligopeptide-modified poly(beta-amino ester)s-coated AdNuPARmE1A: boosting the efficacy of intravenously administered therapeutic adenoviruses
Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina; Brugada Vilà, Pau; Fillat i Fonts, Cristina; Cascante, Anna; Lázaro, Miguel Ángel; Castells-Sala, Cristina; Rovira-Rigau, Maria; Albertazzi, Lorenzo (Theranostics. Vol.10, n.6 (2020), p. 2744-2758, 2020-02)Oncolytic adenoviruses are used as agents for the treatment of cancer. However, their potential is limited due to the high seroprevalence of anti-adenovirus neutralizing antibodies (nAbs) within the ...