Now showing items 1-15 of 15

    • Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Harewood, Rhea; Rothwell, Joseph A.; Bešević, Jelena; Viallon, Vivian; Achaintre, David; Gicquiau, Audrey; Rinaldi, Sabina; Wedekind, Roland; Prehn, Cornelia; Adamski, Jerzy; Schmidt, Julie A.; Jacobs, Inarie; Tjønneland, Anne; Olsen, Anja; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena Andrea; Schulze, Matthias B.; Prada, Marcela; Masala, Giovanna; Agnoli, Claudia; Panico, Salvatore; Sacerdote, Carlotta; Jakszyn, Paula; Sánchez, María-José; Castilla, Jesús; Chirlaque, Maria-Dolores; Aizpurua Atxega, Amaia; Van Guelpen, Bethany; Heath, Alicia K.; Papier, Keren; Tong, Tammy Y. N.; Summers, Scott A.; Playdon, Mary; Cross, Amanda J.; Keski-Rahkonen, Pekka; Chajès, Véronique; Murphy, Neil; Gunter, Marc J. (eBioMedicine, 2024, 101: 105024, 2024-03)
      Background Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods In a case–control study ...
    • Characterization of the degree of food processing in the European Prospective Investigation into Cancer and Nutrition: application of the Nova classification and validation using selected biomarkers of food processing 

      Huybrechts, Inge; Rauber, Fernanda; Nicolas, Geneviève; Casagrande, Corinne; Kliemann, Nathalie; Wedekind, Roland; Biessy, Carine; Scalbert, Augustin; Touvier, Mathilde; Aleksandrova, Krasimira; Jakszyn, Paula; Skeie, Guri; Bajracharya, Rashmita; Boer, Jolanda M.A.; Borné, Yan; Chajes, Veronique; Dahm, Christina C.; Dansero, Lucia; Guevara, Marcela; Heath, Alicia K.; Ibsen, Daniel B.; Papier, Keren; Katzke, Verena Andrea; Kyrø, Cecilie; Masala, Giovanna; Molina-Montes, Esther; Robinson, Oliver J.K.; Santiuste de Pablos, Carmen; Schulze, Matthias B.; Simeon, Vittorio; Sonestedt, Emily; Tjønneland, Anne; Tumino, Rosario; van der Schouw, Yvonne T.; Verschuren, Monique; Vozar, Beatrice; Winkvist, Anna; Gunter, Marc J.; Monteiro, Carlos A.; Millett, Christopher J.; Bertazzi Levy, Renata (Frontiers in Nutrition, 2023, 9:1035580, 2022-12)
      Background: Epidemiological studies have demonstrated an association between the degree of food processing in our diet and the risk of various chronic diseases. Much of this evidence is based on the ...
    • Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study 

      Cordova, Reynalda; Viallon, Vivian; Fontvieille, Emma; Peruchet-Noray, Laia; Jansana-Riera, Anna; Wagner, Karl-Heinz; Kyrø, Cecilie; Tjønneland, Anne; Katzke, Verena Andrea; Bajracharya, Rashmita; Schulze, Matthias B.; Masala, Giovanna; Sieri, Sabina; Panico, Salvatore; Ricceri, Fulvio; Tumino, Rosario; Boer, Jolanda M.A.; Verschuren, Monique; van der Schouw, Yvonne T.; Jakszyn, Paula; Redondo‑Sánchez, Daniel; Amiano, Pilar; Huerta, José María; Guevara, Marcela; Borné, Yan; Sonestedt, Emily; Tsilidis, Konstantinos K.; Millett, Christopher J.; Heath, Alicia K.; Aglago, Elom K; Aune, Dagfnn; Gunter, Marc J.; Ferrari, Pietro; Huybrechts, Inge; Freisling, Heinz (The Lancet Regional Health Europe, 2023, 35: 100771, 2023-12)
      Background It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption ...
    • Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Ersoy Guller, Zeynep Betul; Harewood, Rhea; Weiderpass, Elisabete; Huybrechts, Inge; Jenab, Mazda; Huerta, José María; Sánchez, María-José; Jakszyn, Paula; Amiano, Pilar; Ardanaz, Eva; Agnoli, Claudia; Tumino, Rosario; Palli, Domenico; Skeie, Guri; Manjer, Jonas; Papier, Keren; Tjønneland, Anne; Eriksen, Anne Kirstine; Schulze, Matthias B.; Kaaks, Rudolf; Katzke, Verena Andrea; Bergmann, Manuela M.; Riboli, Elio; Gunter, Marc J.; Cross, Amanda J. (Cancer Causes and Control, 2023, 34: 927-937, 2023-06)
      Purpose The incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk ...
    • Food biodiversity and total and cause-specific mortality in 9 European countries: an analysis of a prospective cohort study 

      Hanley-Cook, Giles T.; Huybrechts, Inge; Biessy, Carine; Remans, Roseline; Kennedy, Gina; Deschasaux-Tanguy, Mélanie; Murray, Kris A.; Touvier, Mathilde; Skeie, Guri; Kesse-Guyot, Emmanuelle; Argaw, Alemayehu; Casagrande, Corinne; Nicolas, Geneviève; Vineis, Paolo; Millett, Christopher J.; Weiderpass, Elisabete; Ferrari, Pietro; Dahm, Christina C.; Bueno de Mesquita, H. Bas; Sandanger, Torkjel M.; Ibsen, Daniel B.; Freisling, Heinz; Ramne, Stina; Jannasch, Franziska; van der Schouw, Yvonne T.; Schulze, Matthias B.; Tsilidis, Konstantinos K.; Tjønneland, Anne; Ardanaz, Eva; Bodén, Stina; Cirera, Lluís; Gargano, Giuliana; Halkjær, Jytte; Jakszyn, Paula; Johansson, Ingegerd; Katzke, Verena Andrea; Masala, Giovanna; Panico, Salvatore; Rodríguez-Barranco, Miguel; Sacerdote, Carlotta; Srour, Bernard; Tumino, Rosario; Riboli, Elio; Gunter, Marc J.; Jones, Andrew D.; Lachat, Carl (PLoS Medicine, 2021, 18(10): e1003834, 2021-10-18)
      Background Food biodiversity, encompassing the variety of plants, animals, and other organisms consumed as food and drink, has intrinsic potential to underpin diverse, nutritious diets and improve Earth ...
    • Identifying metabolomic mediators of the physical activity and colorectal cancer relationship 

      Papadimitriou, Nikos; Kazmi, Nabila; Tsilidis, Konstantinos K.; Richmond, Rebecca C.; Lynch, Brigid M.; Bendinelli, Benedetta; Ricceri, Fulvio; Sánchez, Maria Jose; Trobajo-Sanmartín, Camino; Jakszyn, Paula; Simeon, Vittorio; Severi, Gianluca; Perduca, Vittorio; Truong, Therese; Ferrari, Pietro; Keski-Rahkonen, Pekka; Weiderpass, Elisabete; Eichelmann, Fabian; Schulze, Matthias B.; Katzke, Verena Andrea; Turzanski‑Fortner, Renée; Heath, Alicia K.; Aune, Dagfnn; Harewood, Rhea; Dahm, Christina C.; Llorente, Adrian; Gunter, Marc J.; Murphy, Neil; Lewis, Sarah Jayne (Cancer epidemiology, biomarkers and prevention, 2025, 34(4): 578-587, 2025-04)
      Background: Current evidence suggests higher physical activity (PA) levels are associated with a reduced risk of colorectal cancer. However, the mediating role of the circulating metabolome in this ...
    • Inflammatory potential of diet and pancreatic cancer risk in the EPIC study 

      Cayssials, Valerie; Buckland, Genevieve; Crous-Bou, Marta; Bonet, Catalina; Weiderpass, Elisabete; Skie, Guri; Aune, Dagfnn; Heath, Alicia K.; Nøst, Therese Haugdahl; Masala, Giovanna; Agnoli, Claudia; Santucci de Magistris, Maria; Bueno de Mesquita, H. Bas; Derksen, Jeroen; Huybrechts, Inge; Ferrari, Pietro; Franklin, Oscar; Bodén, Stina; Schulze, Matthias B.; Huerta, José María; Barricarte, Aurelio; Sacerdote, Carlotta; Amiano, Pilar; Tumino, Rosario; Molina-Montes, Esther; Tjønneland, Anne; Kyrø, Cecilie; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Rebours, Vinciane; Katzke, Verena Andrea; Agudo, Antonio; Jakszyn, Paula (European Journal of Nutrition, 2022, 61: 2313-2320, 2022-01)
      Purpose There is existing evidence on the potential role of chronic infammation in the pathogenesis of pancreatic cancer (PC) and on how risk may be modulated by dietary factors. Pro-infammatory diets ...
    • Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study 

      Castro Espin, Carlota; Agudo, Antonio; Bonet, Catalina; Katzke, Verena Andrea; Turzanski‑Fortner, Renée; Aleksandrova, Krasimira; Schulze, Matthias B.; Tjønneland, Anne; Dahm, Christina C.; Quirós, José Ramón; Sánchez, María-José; Amiano, Pilar; Chirlaque, Maria-Dolores; Ardanaz, Eva; Masala, Giovanna; Sieri, Sabina; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; May, Anne-Marie; Bodén, Stina; Gram, Inger Torhild; Skeie, Guri; Laouali, Nasser; Shah, Sanam; Severi, Gianluca; Aune, Dagfnn; Merritt, Melissa; Cairat, Manon; Weiderpass, Elisabete; Riboli, Elio; Dossus, Laure; Jakszyn, Paula (European Journal of Epidemiology, 2021, 36: 953-964, 2021-06)
      The role of chronic infammation on breast cancer (BC) risk remains unclear beyond as an underlying mechanism of obesity and physical activity. We aimed to evaluate the association between the infammatory ...
    • Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study 

      Jakszyn, Paula; Cayssials, Valerie; Buckland, Genevieve; Perez-Cornago, Aurora; Weiderpass, Elisabete; Boeing, Heiner; Bergmann, Manuela M.; Vulcan, Alexandra; Ohlsson, Bodil; Masala, Giovanna; Cross, Amanda J.; Riboli, Elio; Ricceri, Fulvio; Dahm, Christina C.; Nyvang, Dorthe; Katzke, Verena Andrea; Kühn, Tilman; Kyrø, Cecilie; Tjønneland, Anne; Ward, Heather A.; Tsilidis, Konstantinos K.; Skeie, Guri; Sieri, Sabina; Sánchez, María-José; Huerta, José María; Amiano, Pilar; Lasheras-Mayo, Maria Cristina; Ardanaz, Eva; Mahamat-Saleh, Yahya; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Panico, Salvatore; Peppa, Eleni; Trichopoulou, Antonia; Karakatsani, Anna; Tumino, Rosario; Vermeulen, Roel; Jenab, Mazda; Gunter, Marc J.; Agudo, Antonio (International Journal of Cancer, 2020, 147(4): 1027-1039, 2020-08)
      Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined ...
    • Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study 

      Agudo, Antonio; Cayssials, Valerie; Bonet, Catalina; Tjønneland, Anne; Overvad, Kim; Boutron-Ruault, Marie-Christine; Affret, Aurélie; Fagherazzi, Guy; Katzke, Verena Andrea; Schübel, Ruth; Trichopoulou, Antonia; Karakatsani, Anna; La Vecchia, Carlo; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Ricceri, Fulvio; Panico, Salvatore; Bueno de Mesquita, H. Bas; Peeters, Petra H.; Weiderpass, Elisabete; Skeie, Guri; Nøst, Therese Haugdahl; Lasheras-Mayo, Maria Cristina; Rodríguez-Barranco, Miguel; Amiano, Pilar; Chirlaque, Maria-Dolores; Ardanaz, Eva; Ohlsson, Bodil; Dias, Joana A.; Nilsson, Lena M.; Myte, Robin; Khaw, Kay-Tee; Perez-Cornago, Aurora; Gunter, Marc; Huybrechts, Inge; Cross, Amanda J.; Tsilidis, Kostas; Riboli, Elio; Jakszyn, Paula (American Journal of Clinical Nutrition, 2018, 107(4):607-616, 2018-04)
      Background Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the ...
    • Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort 

      Rothwell, Joseph A.; Murphy, Neil; Bešević, Jelena; Kliemann, Nathalie; Jenab, Mazda; Ferrari, Pietro; Achaintre, David; Gicquiau, Audrey; Vozar, Beatrice; Scalbert, Augustin; Huybrechts, Inge; Freisling, Heinz; Prehn, Cornelia; Adamski, Jerzy; Cross, Amanda J.; Pala, Valeria Maria; Boutron-Ruault, Marie-Christine; Dahm, Christina C.; Overvad, Kim; Gram, Inger Torhild; Sandanger, Torkjel M.; Skeie, Guri; Jakszyn, Paula; Tsilidis, Kostas; Aleksandrova, Krasimira; Schulze, Matthias B.; Hughes, David J.; Van Guelpen, Bethany; Bodén, Stina; Sánchez, María-José; Schmidt, Julie A.; Katzke, Verena Andrea; Kühn, Tilman; Colorado-Yohar, Sandra; Tumino, Rosario; Bueno de Mesquita, H. Bas; Vineis, Paolo; Masala, Giovanna; Panico, Salvatore; Eriksen, Anne Kirstine; Tjønneland, Anne; Aune, Dagfnn; Weiderpass, Elisabete; Severi, Gianluca; Chajès, Véronique; Gunter, Marc J. (Clinical Gastroenterology and Hepatology, 2022, 20(5): e1061-e1082, 2022-05)
      Background & Aims Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of ...
    • Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort 

      Perez-Cornago, Aurora; Crowe, Francesca L.; Appleby, Paul N.; Bradbury, Kathryn; Wood, Angela M.; Jakobsen, Marianne Uhre; Johnson, Laura; Sacerdote, Carlotta; Steur, Marinka; Weiderpass, Elisabete; Würtz, Anne Mette; Kühn, Tilman; Katzke, Verena Andrea; Trichopoulou, Antonia; Karakatsani, Anna; La Vecchia, Carlo; Masala, Giovanna; Tumino, Rosario; Panico, Salvatore; Sluijs, Ivonne; Skeie, Guri; Imaz, Liher; Petrova, Dafina; Quirós, José Ramón; Colorado-Yohar, Sandra; Jakszyn, Paula; Melander, Olle; Sonestedt, Emily; Andersson, Jonas; Wennberg, Maria; Aune, Dagfnn; Riboli, Elio; Schulze, Matthias B.; Di Angelantonio, Emanuele; Wareham, Nicholas J.; Danesh, John; Forouhi, Nita G.; Butterworth, Adam S.; Key, Timothy J. (International Journal of Epidemiology, 2021, 50(1): 212-222, 2021-02)
      Background Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable ...
    • Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP‑4) and risk of colorectal cancer 

      Nimptsch, Katharina; Aleksandrova, Krasimira; Thi Pham, Thu; Papadimitriou, Nikos; Janke, Jürgen; Christakoudi, Sofia; Heath, Alicia K.; Olsen, Anja; Tjønneland, Anne; Schulze, Matthias B.; Katzke, Verena Andrea; Kaaks, Rudolf; Van Guelpen, Bethany; Harbs, Justin; Palli, Domenico; Macciotta, Alessandra; Pasanisi, Fabrizio; Colorado-Yohar, Sandra; Guevara, Marcela; Amiano, Pilar; Grioni, Sara; Jakszyn, Paula; Figueiredo, Jane C.; Samadder, N. Jewel; Li, Christopher I.; Moreno, Victor; Potter, John D.; Schoen, Robert E.; Um, Caroline Y.; Weiderpass, Elisabete; Jenab, Mazda; Gunter, Marc J.; Pischon, Tobias (BMC Medicine, 2023, 21: 391, 2023-10)
      Background Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation ...
    • Sex- and site-specific associations of circulating lipocalin 2 and incident colorectal cancer: Results from the EPIC cohort 

      Reichmann, Robin; Nimptsch, Katharina; Pischon, Tobias; Gunter, Marc J.; Jenab, Mazda; Eriksen, Anne Kirstine; Tjonneland, Anne; Janke, Jürgen; Katzke, Verena Andrea; Kaaks, Rudolf; Schulze, Matthias B.; Eichelmann, Fabian; Masala, Giovanna; Sieri, Sabina; Pasanisi, Fabrizio; Tumino, Rosario; Giraudo, Maria Teresa; Rothwell, Joseph A.; Severi, Gianluca; Jakszyn, Paula; Sanchez-Perez, Maria Jose; Amiano, Pilar; Colorado-Yohar, Sandra; Guevara, Marcela; Van Guelpen, Bethany; Aglago, Elom K; Heath, Alicia K.; Smith-Byrne, Karl; Weiderpass, Elisabete; Aleksandrova, Krasimira (International Journal of Cancer, 2025, 156(5): 930-942, 2024-11)
      Experimental research has uncovered lipocalin 2 (LCN2) as a novel biomarker implicated in the modulation of intestinal inflammation, metabolic homeostasis, and colon carcinogenesis. However, evidence ...
    • Ultra‑processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis 

      Morales Berstein, Fernanda; Biessy, Carine; Viallon, Vivian; Goncalves‑Soares, Ana; Casagrande, Corinne; Hémon, Bertrand; Kliemann, Nathalie; Cairat, Manon; Blanco Lopez, Jessica; Al Nahas , Aline; Chang, Kiara; Vamos, Eszter; Rauber, Fernanda; Bertazzi Levy, Renata; Barbosa Cunha, Diana; Jakszyn, Paula; Ferrari, Pietro; Vineis, Paolo; Masala, Giovanna; Catalano, Alberto; Sonestedt, Emily; Borné, Yan; Katzke, Verena Andrea; Bajracharya, Rashmita; Agnoli, Claudia; Guevara, Marcela; Heath, Alicia K.; Radoï, Loredana; Mancini, Francesca; Weiderpass, Elisabete; Huerta, José María; Sánchez, María-José; Tjønneland, Anne; Kyrø, Cecilie; Schulze, Matthias B.; Skeie, Guri; Lukic, Marko; Braaten, Tonje; Gunter, Marc; Millett, Christopher J.; Agudo, Antonio; Brennan, Paul; Borges, M. Carolina; Richmond, Rebecca C.; Richardson, Tom G.; Davey Smith, George; Relton, Caroline L.; Huybrechts, Inge (European Journal of Nutrition, 2024, 63: 377-396, 2023-11)
      Purpose To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European ...