Browsing by Author "Martorell López, Jordi"
Now showing items 1-11 of 11
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1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs
Bosch-Sanz, Oriol; Rabadà, Yvette; Biarnés Fontal, Xevi; Pedreño, Javier; Caveda, Luis; Balcells Camps, Mercedes; Martorell López, Jordi; Sánchez García, David (International Journal of Molecular Sciences, 23(23), 2022, 14942, 2022)Fibrinolysis is a natural process that ensures blood fluidity through the removal of fibrin deposits. However, excessive fibrinolytic activity can lead to complications in different circumstances, such ... -
3D printed polymeric stent design: Mechanical testing and computational modeling
Canalejo Codina, Francesc; Cano Morenilla, Mariola; Martorell López, Jordi; Balcells Camps, Mercedes; Pegueroles, Marta; García Granada, Andrés-Amador (Materials & Design. 2024;247:113395, 2024-10-22)Polymer-based bioresorbable scaffolds (BRS) aim to reduce the long-term issues associated with metal stents. Yet, first-generation BRS designs experienced a significantly higher rate of clinical failures ... -
Fluid-structure interaction simulations outperform computational fluid dynamics in the description of thoracic aorta haemodynamics and in the differentiation of progressive dilation in Marfan syndrome patients
Martorell López, Jordi; Molins Vara, José Javier; Pons, R.; Guala, A.; Rodríguez-Palomares, J.F.; Cajas, J.C.; Dux-Santoy, L.; Teixidó-Tura, G.; Vázquez, M.; Evangelista, A. (Royal Society Open Science. Vol.7, n.2 (2020), 191752, 2020-02)Abnormal fluid dynamics at the ascending aorta may be at the origin of aortic aneurysms. This study was aimed at comparing the performance of computational fluid dynamics (CFD) and fluid–structure ... -
In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections
Balà, Noemí; Aranda, Alejandro; Teixidó, Pau; Molhoek, Carlota; Moreno Jiménez, Inés; Febas, Germán; Lopez-Guimet, Julia; Groothuis, Adam; Edelman, Elazer; Balcells Camps, Mercedes; Borrós i Gómez, Salvador; Martorell López, Jordi; Riambau, Vicente (JACC: Basic to Translational Science. 2024;9(1):65-77, 2024-01-22)Endovascular repair of aortic dissection still presents significant limitations. Preserving the mechanical and biological properties set by the aortic microstructure is critical to the success of ... -
Optimization of 3D autologous chondrocyte-seeded polyglycolic acid scaffolds to mimic human ear cartilage
Melgar Lesmes, Pedro; Bosch-Sanz, Oriol; Zubajlo, Rebecca; Molins, Gemma; Comfort, Sofia; Luque Saavedra, Ainara; López-Moya, Mario; García Polite, Fernando; Parri Ferrandis, Francisco José; Rogers, Carolyn; Gelabertó, Agata; Martorell López, Jordi; Edelman, Elazer R.; Balcells Camps, Mercedes (Biomaterials Science 2023, 13 (10), 2023-05)Auricular reconstruction in children with microtia is one of the more complex procedures in plastic surgery. Obtaining sufficient native material to build an ear requires harvesting large fragments of ... -
Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
Martorell López, Jordi; Polcaro, Alessandro; Troelstra, Marian Amber; Runge, Jurgen Henk; Burnhope, Emma; Guenthner, Christian; Schneider, Torben; Razavi, Reza; Ismail, Tevfik F.; Sinkus, Ralph (Scientific Reports. Vol.11, 1403 (2021), 2021-01)Changes in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance ... -
Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
Troelstra, Marian Amber; Runge, Jurgen Henk; Burnhope, Emma; Polcaro, Alessandro; Guenthner, Christian; Schneider, Torben; Razavi, Reza; Ismail, Tevfik F.; Martorell López, Jordi; Sinkus, Ralph (Scientific Reports, 2021-01-14)Changes in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance ... -
Smooth muscle cells orchestrate the endothelial cell response to flow and injury
Balcells Camps, Mercedes; Martorell López, Jordi; Olivé, Carla; Santacana, Marina; Chitalia, Vipul C.; Cardoso, Angelo A.; Edelman, Elazer R. (Circulation. Vol.121, n.20 (2010), p.2192–2199, 2010-05)Background—Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation after endovascular interventions but may be associated with endothelial ... -
Unravelling the Antifibrinolytic Mechanism of Action of the 1,2,3-Triazole Derivatives
Rabadà, Yvette; Bosch-Sanz, Oriol; Biarnés Fontal, Xevi; Pedreño, Javier; Caveda, Luis; Sánchez García, David; Martorell López, Jordi; Balcells Camps, Mercedes (International Journal of Molecular Sciences. 2024;25(13):7002, 2024-06-26)A new family of antifibrinolytic drugs has been recently discovered, combining a triazole moiety, an oxadiazolone, and a terminal amine. Two of the molecules of this family have shown activity that is ... -
Uremic serum and solutes increase post-vascular interventional thrombotic risk through altered stability of smooth muscle cell tissue factor
Balcells Camps, Mercedes; Martorell López, Jordi; Chitalia, Vipul C.; Shivanna, Sowmya; Bosch, Irene; Kolandaivelu, Kumaran; Edelman, Elazer R. (Circulation. Vol.127, n.3 (2013), p.365–376, 2013-01)Background—Stent thrombosis (ST), a postinterventional complication with a mortality rate of 50%, has an incidence that rises precipitously in patients at risk. Chronic renal failure and end-stage renal ... -
Versatile, elastomeric and degradable polyHIPEs of poly(glycerol sebacate)-methacrylate and their application in vascular graft tissue-engineering
Pashneh-Tala, Samand; Field, Jonathan; Fornesa, Blanca; Molins Colomer, Maite; Jackson, Caitlin E.; Balcells Camps, Mercedes; Martorell López, Jordi; Claeyssens, Frederik (Materials Today Advances 2023, 20, 100432, 2023-12)Polymer scaffolds are an important enabling technology in tissue engineering. A wide range of manufacturing techniques have been developed to produce these scaffolds, including porogen leaching, phase ...