Browsing by Author "Semino, Carlos"
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Culture and differentiation of human hair follicle dermal papilla cells in a soft 3D self-assembling peptide scaffold
Semino, Carlos; Betriu, Nausika; Jarrosson-Moral, Claire (Biomolecules. Vol.10, n.5 (2020), 684, 2020-05)Hair follicle dermal papilla cells (HFDPC) are a specialized cell population located in the bulge of the hair follicle with unique characteristics such as aggregative behavior and the ability to induce ... -
Dedifferentiated human articular chondrocytes redifferentiate to a cartilage-like tissue phenotype in a poly(ε-caprolactone)/self-assembling peptide composite scaffold
Semino, Carlos; Abellà, Jordi (Abellà i Iglesias); Recha Sancho, Lourdes Georgina; Moutos, Franklin T.; Guilak, Farshid (Materials. Vol.9, n.6 (2016), 472, 2016-06)Adult articular cartilage has a limited capacity for growth and regeneration and, with injury, new cellular or biomaterial-based therapeutic platforms are required to promote repair. Tissue engineering ... -
Development of a three-dimensional bioengineered platform for articular cartilage regeneration
Semino, Carlos; Rubí-Sans, Gerard; Recha Sancho, Lourdes Georgina; Pérez-Amodio, Soledad; Mateos-Timoneda, Miguel Ángel; Engel, Elisabeth (Biomolecules. Vol.10, n.1 (2020), 52, 2019-12)Degenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, ... -
Epithelial to mesenchymal transition in human endocrine islet cells
Semino, Carlos; Aloy Reverté, Caterina; Moreno Amador, José Luis; Téllez i Besolí, Noèlia; Marin, Sandra; Nacher, Montserrat; Montanya Mias, Eduard (PLoS One. Vol. 13, n.1 (2018), p. e0191104, 2018-01)Background β-cells undergo an epithelial to mesenchymal transition (EMT) when expanded in monolayer culture and give rise to highly proliferative mesenchymal cells that retain the potential to ... -
Erlotinib Promotes Ligand-Induced EGFR Degradation in 3D but Not 2D Cultures of Pancreatic Ductal Adenocarcinoma Cells
Betriu, Nausika; Semino, Carlos; Andreeva, Anna (Cancers, 2021-09-07)The epithelial growth factor receptor (EGFR) is a tyrosine kinase receptor that participates in many biological processes such as cell proliferation. In addition, EGFR is overexpressed in many epithelial ... -
Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds
Betriu, Nausika; Andreeva, Anna; Alonso, Anna; Semino, Carlos (Biomedicines 2022, 10(8), 1835, 2022-08)The focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that participates in integrin-mediated signal transduction and contributes to different biological processes, such as cell migration, ... -
Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model
Semino, Carlos; Sennett, M. L.; Friedman, J. M.; Ashley, B. S.; Stoeckl, B. D.; Patel, J. M.; Alini, M.; Cucchiarini, M.; Eglin, D.; Madry, H.; Mata, A.; Stoddart, M. J.; Johnstone, B.; Moutos, Franklin T.; Estes, B. T.; Guilak, Farshid; Mauck, R. L.; Dodge, G. R. (European Cells & Materials Journal, 2021-01-07)The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics. Chondral defects may arise from a variety of joint pathologies and left untreated, will likely ... -
Syndecans and Pancreatic Ductal Adenocarcinoma
Betriu, Nausika; Bertran-Mas, Juan; Andreeva, Anna; Alonso, Anna; Semino, Carlos (Biomolecules, 2021-02-25)Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal disease with poor prognosis because patients rarely express symptoms in initial stages, which prevents early detection and diagnosis. Syndecans, a ... -
Three-dimensional tumor-stroma co-culture system development using self-assembling peptide scaffolds
Semino, Carlos; Betriu, C. (Afinidad. Vol.76, n.587 (2019), p.163-170, 2019-07)Cancer research has traditionally relied on 2D cell culture, focusing mainly on cancer cells and its disrupted genetics. However, tumors have been accepted as complex tissues, and as such, they need ... -
β-Sheet to Random Coil Transition in Self-Assembling Peptide Scaffolds Promotes Proteolytic Degradation
Genové, Elsa; Betriu, Nausika; Semino, Carlos (Biomolecules 2022, 12(3), 411, 2022-03)One of the most desirable properties that biomaterials designed for tissue engineering or drug delivery applications should fulfill is biodegradation and resorption without toxicity. Therefore, there ...