Now showing items 1-20 of 41

    • A comparative study on two cationic porphycenes: photophysical and antimicrobial photoinactivation evaluation 

      Nonell, Santi; Agut Bonsfills, Montserrat; Ruiz González, Rubén; Reddi, Elena (International Journal of Molecular Sciences. Vol.16, n.11 (2015), p.27072-27086, 2015-11)
      Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial ...
    • A Double Payload Complex between Hypericin and All-trans Retinoic Acid in the β-Lactoglobulin Protein 

      Rodríguez Amigo, Beatriz; Hally, Cormac; Roig Yanovsky, Núria; Delcanale, Pietro; Abbruzzetti, Stefania; Agut Bonsfills, Montserrat; Viappiani, Cristiano; Nonell, Santi (Antibiotics, 11(2), 2022, 282, 2022)
      Combined therapies are usually used to treat acne vulgaris since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques ...
    • A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditions 

      Ortega Forte, Enrique; Rovira, Anna; López Corrales, Marta; Hernández García, Alba; Ballester, Francisco José; Izquierdo García, Eduardo; Jordà Redondo, Mireia; Bosch, Manel; Nonell, Santi; Santana, María Dolores; Ruiz, José; Marchán, Vicente; Gasser, Gilles (Chemical Space 2023, 15(26), 2023-07-14)
      Photodynamic therapy (PDT) represents a promising approach for cancer treatment. However, the oxygen dependency of PDT to generate reactive oxygen species (ROS) hampers its therapeutic efficacy, especially ...
    • A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents 

      Nonell, Santi; Planas, Oriol; Gallavardin, Thibault (Chemical Communications. Vol.51, n.26 (2015), p.5586-5589, 2014-12)
      Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The ...
    • An Ultra-Long-Lived Triplet Excited State in Water at Room Temperature: Insights on the Molecular Design of Tridecafullerenes 

      Ramos-Soriano, Javier; Pérez-Sánchez, Alfonso; Ramírez-Barroso, Sergio; Beatriz, Illescas; Rodriguez-Fortea, Antonio; Poblet, Josep M.; Hally, Cormac; Nonell, Santi; García-Fresnadillo, David; Rojo, Javier; Martín, Nazario; Azmani, Khalid (Angewandte Chemie International Edition, 2021-05-13)
      Suitably engineered molecular systems exhibiting triplet excited states with very long lifetimes are important for high-end applications in nonlinear optics, photocatalysis, or biomedicine. We report ...
    • Assessing amphiphilic ABAB Zn(II) Phthalocyanines with enhanced photosensitization abilities in In Vitro photodynamic therapy studies against cancer 

      Nonell, Santi; Juarranz, Ángeles; De la Torre, Gema; Torres, Tomás; Revuelta-Maza, Miguel Á.; Mascaraque, Marta; González-Jiménez, Patricia; González-Camuñas, Arturo (Molecules. Vol.25, n.1 (2020), 213, 2020-01)
      We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., ...
    • Assessing the potential of photosensitizing flavoproteins as tags for correlative microscopy 

      Nonell, Santi; Ruiz González, Rubén; Torra, Joaquim; Rodríguez-Pulido, Alberto; Cortajarena, Aitziber L.; Flors, Cristina (Chemical Communications. Vol.52, n.54 (2016), p.8405-8408, 2016-06)
      Photosensitizing flavoproteins have great potential as tags for correlative light and electron microscopy (CLEM). We examine the photostability of miniSOG mutants and their ability to photooxidize ...
    • Bactericidal effect of photodynamic therapy, alone or in combination with mupirocin or linezolid, on Staphylococcus aureus 

      Nonell, Santi; Pérez-Laguna, Vanesa; Pérez-Artiaga, Luna; Lampaya-Pérez, Verónica; García-Luque, Isabel; Ballesta, Sofía; Paz-Cristobal, Manuel P.; Gilaberte, Yolanda; Rezusta, Antonio (Frontiers in Microbiology. Vol. 8 (2017), 1002, 2017-05)
      Antibiotic treatments frequently fail due to the development of antibiotic resistance, underscoring the need for new treatment strategies. Antimicrobial photodynamic therapy (aPDT) could constitute an ...
    • Carminic acid linked to silica nanoparticles as pigment/antioxidant bifunctional excipient for pharmaceutical emulsions 

      Nonell, Santi; Morales, Javier; Arriagada, Francisco; Ugarte, Catalina; Günther, Germán; Larraín, María Angélica; Guarnizo-Herrero, Víctor (Pharmaceutics. Vol.12, n.4 (2020), 376, 2020-04)
      The incorporation of pigments and natural polyphenols into inorganic matrices, resulting in a hybrid material that improves the resistance and chemical stability of the pigments and the antioxidant ...
    • Cluster and Kill: the Use of Clustering-Triggered Emission Materials for Singlet Oxygen Photosensitization in Antimicrobial Photodynamic Therapy 

      Dueñas Parro, Karina; Gulias, Oscar; Agut Bonsfills, Montserrat; de la Cruz-Martínez, Felipe; Lara Sánchez, Agustín; Castro Osma, José A.; García Reyes, Juan F.; Sánchez Ruiz, Antonio; Martín, Cristina; Nonell, Santi; Bresolí Obach, Roger (Advanced Optical Materials 2025, 13 (3), 2402179, 2025-01-24)
      The emergence of light-based technologies is revolutionizing modern medicine and healthcare by enabling precise disease diagnosis and treatment through various luminescent agents and imaging techniques. ...
    • Development of green/red-absorbing chromophores based on a coumarin scaffold that are useful as caging groups 

      Nonell, Santi; Gandioso, Albert; Contreras, Sara; Melnyk, Ivanna; Oliva, Javier; Velasco Castrillo, Dolores; Garcia Amorós, Jaume; Marchán Sancho, Vicente (Journal of Organic Chemistry. Vol.82, n.10 (2017), p.5398-5408, 2017-05)
      We report the design, synthesis, and spectroscopic characterization of a series of push–pull chromophores based on a novel coumarin scaffold in which the carbonyl of the lactone function of the original ...
    • Do folate-receptor targeted liposomal photosensitizers enhance photodynamic therapy selectivity? 

      Nonell, Santi; García Díaz, María; Sagristá, M. Lluïsa; Villanueva, Ángeles; Stockert, Juan Carlos; Cañete, Magdalena; Casadó, Ana; Mora, Margarita (Biochimica et Biophysica Acta (BBA) -Biomembranes. Vol.1808, n.4 (2011), p.1063-1071, 2011-01)
      One of the current goals in photodynamic therapy research is to enhance the selective targeting of tumor cells in order to minimize the risk and the extension of unwanted side-effects caused by normal ...
    • Dual-Functionalized Nanoliposomes Achieve a Synergistic Chemo-Phototherapeutic Effect 

      Lazaro Carrillo, Ana; Rodríguez Amigo, Beatriz; Mora, Margarita; Sagristá, M. Lluïsa; Cañete, Magdalena; Nonell, Santi; Villanueva, Ángeles (International Journal of Molecular Sciences, 23(21), 2022, 12817, 2022)
      The enhancement of photodynamic therapy (PDT) effectiveness by combining it with other treatment modalities and improved drug delivery has become an interesting field in cancer research. We have prepared ...
    • Effective photodynamic inactivation of 26 Escherichia coli strains with different antibiotic susceptibility profiles: a planktonic and biofilm study 

      Nonell, Santi; Agut Bonsfills, Montserrat; Gulías Borau, Òscar; McKenzie, Giselle; Bayó, Miquel (Antibiotics. Vol.9, n.3 (2020), 98, 2020-02)
      The emergence of multidrug-resistant bacteria is a growing problem and alternative therapies are being sought to effectively address this issue. The aim of this study is to assess a range of Escherichia ...
    • Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates 

      Rovira, Anna; Ortega Forte, Enrique; Hally, Cormac; Jordà Redondo, Mireia; Abad-Montero, Diego; Vigueras, Gloria; Martínez, Jesús I.; Bosch, Manel; Nonell, Santi; Ruiz, José; Marchán, Vicente (Journal of Medicinal Chemistry 2023, 66 (12), 2023-06-22)
      Photodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under ...
    • Heteroacoplamientos catalizados por paladio 

      Teixidó i Closa, Jordi; Sánchez García, David; Borrós i Gómez, Salvador; Nonell, Santi; Borrell Bilbao, José Ignacio; Colominas Guàrdia, Carles (Afinidad. Vol.59, n.500 (2002), p.325-336, 2002)
      Durante los diez últimos años la química del paladio se ha aplicado intensamente en síntesis orgánica debido a su versatilidad y a su gran selectividad. En esta breve revisión se muestran las características ...
    • High photostability in nonconventional coumarins with far-red/NIR emission through azetidinyl substitution 

      Nonell, Santi; Bresolí Obach, Roger; Gandioso, Albert; Palau Requena, Marta; Galindo Muñoz, Alex; Rovira, Anna; Bosch, Manel; Marchán Sancho, Vicente (Journal of Organic Chemistry. Vol.83, n.19 (2018), p.11519-11531, 2018-08)
      Replacement of electron-donating N,N-dialkyl groups with three- or four-membered cyclic amines (e.g., aziridine and azetidine, respectively) has been described as a promising approach to improve some ...
    • Innovative light sources for phototherapy 

      Romano, Giovanni; Insero, Giacomo; Nonell, Santi; Fusi, Franco (Biomolecular Concepts 2022, 13(1), 256-271, 2022)
      The use of light for therapeutic purposes dates back to ancient Egypt, where the sun itself was an innovative source, probably used for the first time to heal skin diseases. Since then, technical ...
    • Mitochondria-Targeted COUPY Photocages: Synthesis and Visible-Light Photoactivation in Living Cells 

      López Corrales, Marta; Rovira, Anna; Gandioso, Albert; Nonell, Santi; Bosch, Manel; Marchán, Vicente (The Journal of Organic Chemistry 2023, 88, 7128-7140, 2023-06-02)
      Releasing bioactive molecules in specific subcellular locations from the corresponding caged precursors offers great potential in photopharmacology, especially when using biologically compatible visible ...
    • Morin flavonoid adsorbed on mesoporous silica, a novel antioxidant nanomaterial 

      Arriagada, Francisco; Correa, Olosmira; Günther, Germán; Nonell, Santi; Mura, Francisco; Olea-Azar, Claudio; Morales, Javier (Plos One, 2016, vol.11, 2016-11-03)
      Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in ...