Browsing by Author "Guerra Rebollo, Marta"
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Application of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas
Fornaguera Puigvert, Cristina; Lázaro, Miguel Ángel; Brugada Vilà, Pau; Porcar, Irene; Morera, Ingrid; Guerra Rebollo, Marta; Garrido, Cristina; Blanco, Jeronimo; Cascante, Anna; Borrós i Gómez, Salvador (Drug Delivery, 2018-02-07)Glioblastoma multiforme (GBM) is the most devastating primary brain tumor due to its infiltrating and diffuse growth characteristics, a situation compounded by the lack of effective treatments. Currently, ... -
CRISPR/Cas9-Mediated Knockin Application in Cell Therapy: A Non-viral Procedure for Bystander Treatment of Glioma in Mice
Meca Cortés, Oscar; Guerra Rebollo, Marta; Garrido, Cristina; Borrós i Gómez, Salvador; Rubio, Nuria; Blanco, Jeronimo (Molecular Therapy: Nucleic Acids, 2017-07-26)The use of non-viral procedures, together with CRISPR/Cas9 genome-editing technology, allows the insertion of single-copy therapeutic genes at pre-determined genomic sites, overcoming safety limitations ... -
Dynamic Combinatorial Optimization of In Vitro and In Vivo Heparin Antidotes
Carbajo López, Daniel; Guerra Rebollo, Marta; Bujons, Jordi; Alfonso, Ignacio; Prats, Eva (American Chemical Society, 2022-03-02)Heparin-like macromolecules are widely used in clinics as anticoagulant, antiviral, and anticancer drugs. However, the search of heparin antidotes based on small synthetic molecules to control blood ... -
Electrostatic Coating of Viral Particles for Gene Delivery Applications in Muscular Dystrophies: Influence of Size on Stability and Antibody Protection
Guerra Rebollo, Marta; Stampa, María; Lázaro, Miguel Ángel; Cascante, Anna; Fornaguera Puigvert, Cristina; Borrós i Gómez, Salvador (Journal of Neuromuscular Diseases, vol. 8, no. 5, pp. 815-825, 2021-09-14)Background:Duchenne Muscular Dystrophy (DMD) is one of the most common muscular dystrophies, caused by mutated forms of the dystrophin gene. Currently, the only treatment available is symptoms management. ... -
Engineered microtissues for the bystander therapy against cancer
Blanco-Fernandez, Barbara; Cano-Torres, Irene; Garrido, Cristina; Rubí-Sans, Gerard; Sánchez-Cid, Lourdes; Guerra Rebollo, Marta; Rubio, Nuria; Blanco, Jeronimo; Pérez-Amodio, Soledad; Mateos-Timoneda, Miguel Ángel; Engel, Elisabeth (Materials Science and Engineering C, 2021-01-13)Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this ... -
Novel α-mannose-functionalized poly(β-amino ester) nanoparticles as mRNA vaccines with increased antigen presenting cell selectivity in the spleen
González-Ríos, Nil; Artigues Cladera, Margalida; Guerra Rebollo, Marta; Planas, Antoni (Planas Sauter); Borrós i Gómez, Salvador; Faijes, Magda; Fornaguera Puigvert, Cristina (Journal of Materials Chemistry B, 2023-06-14)mRNA vaccination has emerged as a prominent therapy for the future of medicine. Despite the colossal advance in this technology and worldwide efficacy proof (ca. COVID vaccines), mRNA carriers still ... -
Nucleic acid-loaded poly(beta-aminoester) nanoparticles for cancer nano-immuno therapeutics
Magaña Rodriguez, J. Rodrigo; Guerra Rebollo, Marta; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina (Drug Delivery and Translational Research. 2024;14:3477–3493, 2024-05-03)Immunotherapy has emerged as a promising approach to cancer treatment, offering improved survival rates and enhanced patients’ quality of life. However, realizing the full potential of immunotherapy in ... -
Regulation of mitochondrial apoptosis via siRNA-loaded metallo-alginate hydrogels: A localized and synergistic antitumor therapy
Fernandez Alarcon, Jennifer; Artigues Cladera, Margalida; Rodriguez Camenforte, Natalia; Sitia, Giovanni; Guerra Rebollo, Marta; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina (Biomaterials 2025, 318, 2025-07)Preventing relapse after resection of a primary tumor continues to be an unmet clinical need. Development of adjuvant biomaterials with the capacity to kill residual cancer cells after tumor resection ... -
Stealth mRNA nanovaccines to control lymph node trafficking
García-Fernández, Coral; Virgilio, Tommaso; Latino, Irene; Guerra Rebollo, Marta; F. Gonzalez, Santiago; Borrós i Gómez, Salvador; Fornaguera Puigvert, Cristina (Journal of Controlled Release. 2024;374:325-336, 2024-08-22)mRNA-based vaccines symbolize a new paradigm shift in personalized medicine for the treatment of infectious and non-infectious diseases. However, the reactogenicity associated with the currently approved ...