Glycogenin is dispensable for normal liver glycogen metabolism and body glucose homeostasis
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Data de publicació
2025-02ISSN
1879-0003
Resum
Glycogen is a glucose-storage polysaccharide molecule present in animals, fungi and bacteria. The enzyme glycogenin can self-glycosylate, forming an oligosaccharide chain that primes glycogen synthesis. This priming role of glycogenin was first believed to be essential for glycogen synthesis, but glycogen was then found in the skeletal muscle, heart, liver and brain of glycogenin-knockout mice (Gyg KO), thereby showing that glycogen can be synthesized without glycogenin. Within the liver, glycogen is present in the form of individual glycogen particles, called β particles, and larger composite aggregates of linked β particles, called α particles. Previous studies suggested that liver glycogenin plays a role in linking β particles into α particles and thus participating in glucose homeostasis, which implies that α particles would be absent in Gyg KO mice liver. Here we test this through targeted characterization of glycogen structure and through proteomic and metabolic studies on Gyg KO mice. The results show that, contrary to what had been believed, glycogenin is not necessary for normal liver-glycogen metabolism.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
547 - Química orgànica
577 - Bioquímica. Biologia molecular. Biofísica
Paraules clau
Glycogen
Glycogenin
Glucose metabolism
Glycogen α particles
Liver
Glicogen
Glucosa--Metabolisme
Fetge
Pàgines
p.13
Publicat per
Elsevier
Publicat a
International Journal of Biological Macromolecules 2025, 291, 139084
Número de l'acord de la subvenció
info:eu-repo/grantAgreement/MCI/PN I+D/PID2020-118699GB-I00
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