PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

Cosialls, Raúl; Simó, Cristina; Borrós i Gómez, Salvador; Gómez Vallejo, Vanessa; Schmidt, Claudia; Llop, Jordi; Cuenca, Ana B.; Casini, Angela

Publication date

2023-01-12

URI http://hdl.handle.net/20.500.14342/4695

DOI

https://doi.org/10.1002/chem.202202604

ISSN

1521-3765

Abstract

To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

Document Type

Article

Document version

Published version

Language

English

Subject (CDU)

54 - Chemistry. Crystallography. Mineralogy

577 - Material bases of life. Biochemistry. Molecular biology. Biophysics

Keywords

Ammonium trifluoroborates

Cisplatin

Drug delivery

Metallacages

PET imaging

Self-assembly

Amoni

Cisplatí

Medicaments--Modes d'administració

Pages

p.7

Publisher

Wiley

Is part of

Chemistry – A European Journal 2023, 29(3), e202202604

Grant agreement number

info:eu-repo/grantAgreement/MCI/PN I+D/PID2020-113661GB-I00

info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 01051

info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 00294

info:eu-repo/grantAgreement/MCI/PN I+D/PID2020-117656RB-I00

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Rights

Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/